Beyond nylon 6: polyamides via ring opening polymerization of designer lactam monomers for biomedical applications,Chemical Society Reviews

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Beyond nylon 6: polyamides via ring opening polymerization of designer lactam monomers for biomedical applications
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-09-01 , DOI: 10.1039/d1cs00930c
Maria Varghese ₁ , Mark W Grinstaff ₁

Affiliation

Ring opening polymerization (ROP) of lactams is a highly efficient and versatile method to synthesize polyamides. Within the last ten years, significant advances in polymerization methodology and monomer diversity are ushering in a new era of polyamide chemistry. We begin with a discussion of polymerization techniques including the most widely used anionic ring opening polymerization (AROP), and less prevalent cationic ROP and enzyme-catalyzed ROP. Next, we describe new monomers being explored for ROP with increased functionality and stereochemistry. We emphasize the relationships between composition, structure, and properties, and how chemists can control composition and structure to dictate a desired property or performance. Finally, we discuss biomedical applications of the synthesized polyamides, specifically as biomaterials and pharmaceuticals, with examples to include as antimicrobial agents, cell adhesion substrates, and drug delivery scaffolds.

中文翻译：

超越尼龙 6：通过设计内酰胺单体的开环聚合获得聚酰胺，用于生物医学应用

内酰胺的开环聚合（ROP）是一种高效且通用的聚酰胺合成方法。在过去十年中，聚合方法和单体多样性的重大进步正在开创聚酰胺化学的新时代。我们首先讨论聚合技术，包括最广泛使用的阴离子开环聚合 (AROP)、不太流行的阳离子 ROP 和酶催化 ROP。接下来，我们描述了正在为 ROP 探索的具有增强功能和立体化学的新单体。我们强调成分、结构和性质之间的关系，以及化学家如何控制成分和结构以决定所需的性质或性能。最后，我们讨论了合成聚酰胺的生物医学应用，特别是作为生物材料和药物，包括作为抗菌剂、细胞粘附基质和药物输送支架的例子。

更新日期：2022-09-01

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