Currently, no reports exist on the phenomenon of early response in humanistic-experiential therapies. This study investigated the prognostic value of early response on posttreatment outcomes in person-centered experiential therapy (PCET) for depression within the English Improving Access to Psychological Therapies program. The design of the study was a retrospective observational cohort study. Routine clinical data were drawn from N = 3,321 patients with depression symptoms. The primary outcome was reliable and clinically significant improvement (RCSI) on the Patient Health Questionnaire-9 (PHQ-9) self-report depression measure at the end of treatment. Early response was operationalized as reliable improvement, defined as a PHQ-9 change score ≥ 6 from baseline to Session 4. Early response was examined as a predictor of RCSI using logistic regression controlling for baseline depression severity. In sensitivity analyses, therapist effects were controlled using multilevel modeling. A total of 38.7% of patients met the criterion for early response. Patients who experienced an early response to treatment were six times more likely to recover at the end of treatment compared to patients who did not have an early response. The early response effect was still evident after accounting for individual variability between therapists. However, a quarter of patients displayed a pattern of eventual response, reaching recovery at end of treatment despite not experiencing an initial improvement early in therapy. Early response to PCET is a reliable predictor of treatment outcome. Different response patterns evidenced in this study indicate that identifying subgroups of patients associated with early and eventual response could support clinical decision-making. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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早期反应作为以人为中心的抑郁症体验疗法的预后指标。

目前，尚无关于人文体验疗法早期反应现象的报道。本研究调查了英国改善心理治疗机会计划中以人为中心的抑郁症体验式治疗 (PCET) 治疗后结果的早期反应的预后价值。该研究的设计是一项回顾性观察队列研究。常规临床数据来自 3,321 名有抑郁症状的患者。主要结局是治疗结束时患者健康问卷 9 (PHQ-9) 自我报告抑郁症测量结果可靠且具有临床显着性改善 (RCSI)。早期响应被视为可靠的改进，定义为从基线到第 4 节的 PHQ-9 变化评分≥6。使用逻辑回归控制基线抑郁严重程度，检查早期反应作为 RCSI 的预测因子。在敏感性分析中，使用多层次模型控制治疗师的效果。共有38.7%的患者符合早期缓解标准。与没有早期反应的患者相比，对治疗有早期反应的患者在治疗结束时康复的可能性高出六倍。考虑到治疗师之间的个体差异后，早期反应效果仍然很明显。然而，四分之一的患者表现出最终反应模式，尽管在治疗早期并未出现初步改善，但在治疗结束时达到了康复。PCET 的早期反应是治疗结果的可靠预测指标。本研究中证明的不同反应模式表明，识别与早期和最终反应相关的患者亚组可以支持临床决策。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。