Polyphenol-Incorporated Composite Nanogels of Multimodal Interactions for Enhanced Gel Stability and Cisplatin Delivery,ACS Macro Letters

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Polyphenol-Incorporated Composite Nanogels of Multimodal Interactions for Enhanced Gel Stability and Cisplatin Delivery
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-08-31 , DOI: 10.1021/acsmacrolett.2c00419
So-Lee Baek ₁ , Yeojin Kim ₁ , Yoojin Jang ₁ , Sang-Min Lee ₁

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Naturally abundant polyphenols that can readily undergo the facile cross-linking of polymer chains have been of great interest for functional hydrogel formation and its potential biomedical applications. Herein, we report that the internal incorporation of tannic acid (TA) as a natural polyphenol additive at the chitosan-based nanogel templates can enhance the self-association of physically cross-linked polymer networks upon dilution, as well as the colloidal gel stability in protein solution. This is driven by the multivalent hydrogen bonding and π-stacking capability of TA, as verified by the viscosity estimation of diluted nanogel solution, coupled to the conformation-dependent excimer emission of stacked fluorophores in polymer networks, which also allows for the Stern–Volmer analysis of the TA-induced quenching property. Furthermore, the excellent coordination generality of TA for versatile metallic cations enables the facile immobilization of a cisplatin pharmacophore inside the nanogels for acid-sensitive drug release and the potential delivery of metallic components.

中文翻译：

多峰相互作用的多酚复合纳米凝胶增强凝胶稳定性和顺铂递送

天然丰富的多酚可以很容易地进行聚合物链的轻松交联，这对于功能性水凝胶的形成及其潜在的生物医学应用引起了极大的兴趣。在这里，我们报道了在壳聚糖基纳米凝胶模板中加入单宁酸（TA）作为天然多酚添加剂，可以增强稀释后物理交联聚合物网络的自缔合，以及胶体凝胶稳定性。蛋白质溶液。这是由 TA 的多价氢键和 π 堆叠能力驱动的，正如稀释的纳米凝胶溶液的粘度估计所证实的那样，再加上聚合物网络中堆叠荧光团的构象依赖性准分子发射，这也允许 Stern-Volmer TA诱导的猝灭特性分析。此外，

更新日期：2022-08-31

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