The purpose of this study was to compare complications and the number of ghrelin-expressing cells (GECs) after bariatric arterial embolization (BAE) using soluble gelatin sponge particles (SGSs) or tris-acryl gelatin microspheres (MSs) in swine. Twelve swine underwent embolization of gastric fundal arteries with SGSs (n = 4) or MSs (n = 4) or underwent saline infusion (n = 4, control group). One week later, the number of gastric ulcers and the percentage of GECs were compared among the 3 groups. There were no ulcers in the SGS and control groups. Two swine in the MS group had 4 large ulcers (12–50 mm in size). The mean percentages of GECs were significantly lower in the SGS (2.7% ± 0.9%) and MS (2.5% ± 1.0%) groups compared with the control group (3.7% ± 1.3%; P = .038 and P = .016, respectively). SGSs may be safer than MSs for BAE while inducing a similar reduction of GECs in swine.

本研究的目的是比较使用可溶性明胶海绵颗粒 (SGS) 或三丙烯酸明胶微球 (MS) 在猪中进行肥胖动脉栓塞 (BAE) 后的并发症和表达 ghrelin 的细胞 (GEC) 的数量。12 头猪用 SGS（n = 4）或 MS（n = 4）栓塞胃底动脉或接受盐水输注（n = 4，对照组）。1周后比较3组胃溃疡数及GECs百分比。SGS 组和对照组均未出现溃疡。MS 组中的两只猪有 4 个大溃疡（大小为 12-50 毫米）。与对照组（3.7% ± 1.3%；P  = .038 和P = .016，分别）。对于 BAE，SGS 可能比 MS 更安全，同时诱导猪中 GEC 的类似减少。