Pathological cardiac damage during heart failure is associated with cell death and damage associated molecular patterns (DAMPs) release which triggers a viscous cycle of sterile inflammation to mediate maladaptive cardiac tissue remodelling during the progression to heart failure. DAMPs like cytokines, chemokines, and nuclear or mitochondrial genomic fragments are released in the pathological myocardium. Interestingly, circulating or cytosolic DNA fragments can play a role in the disease by interaction with nucleic acid sensors expressed in cardiomyocyte and non-myocyte neighbouring cells. The circulating cell free DNA (cfDNA) fragments have been clinically reported as markers for various diseases including cardiovascular pathophysiology. Such cfDNA within the DAMP pool can mediate intra- and inter-cellular signalling cascade to upregulate transcriptional expression of inflammatory mediators and trigger oxidative stress within cells. The cellular role of such genomic equivalents varying with chronic or acute stress might be correlated with the cell death forms encountered in myocardium during disease progression. Thus, cfDNA can be phenotypically correlated as a critical player towards upregulation of pathological processes like interstitial fibrosis, cardiomyocyte contractile dysfunction and cell death. Herein, we review the association of cfDNA with heart failure and analyse their potential usage as novel and effective therapeutic targets towards augmentation of cardiac function.

心力衰竭期间的病理性心脏损伤与细胞死亡和损伤相关分子模式 (DAMP) 释放有关，这会触发无菌炎症的粘性循环，从而在心力衰竭进展过程中介导适应不良的心脏组织重塑。病理心肌中释放细胞因子、趋化因子和核或线粒体基因组片段等 DAMP。有趣的是，循环或胞质 DNA 片段可以通过与心肌细胞和非肌细胞邻近细胞中表达的核酸传感器相互作用而在疾病中发挥作用。临床报道循环游离 DNA (cfDNA) 片段可作为包括心血管病理生理学在内的多种疾病的标记物。DAMP 库中的此类 cfDNA 可以介导细胞内和细胞间信号级联，从而上调炎症介质的转录表达并触发细胞内的氧化应激。此类基因组等价物随慢性或急性应激而变化的细胞作用可能与疾病进展过程中心肌中遇到的细胞死亡形式相关。因此，cfDNA 在表型上可能是上调间质纤维化、心肌细胞收缩功能障碍和细胞死亡等病理过程的关键参与者。在此，我们回顾了 cfDNA 与心力衰竭的关联，并分析了它们作为增强心脏功能的新型有效治疗靶点的潜在用途。此类基因组等价物随慢性或急性应激而变化的细胞作用可能与疾病进展过程中心肌中遇到的细胞死亡形式相关。因此，cfDNA 在表型上可能是上调间质纤维化、心肌细胞收缩功能障碍和细胞死亡等病理过程的关键参与者。在此，我们回顾了 cfDNA 与心力衰竭的关联，并分析了它们作为增强心脏功能的新型有效治疗靶点的潜在用途。此类基因组等价物随慢性或急性应激而变化的细胞作用可能与疾病进展过程中心肌中遇到的细胞死亡形式相关。因此，cfDNA 在表型上可能是上调间质纤维化、心肌细胞收缩功能障碍和细胞死亡等病理过程的关键参与者。在此，我们回顾了 cfDNA 与心力衰竭的关联，并分析了它们作为增强心脏功能的新型有效治疗靶点的潜在用途。cfDNA 在表型上可以作为间质纤维化、心肌细胞收缩功能障碍和细胞死亡等病理过程上调的关键参与者相关。在此，我们回顾了 cfDNA 与心力衰竭的关联，并分析了它们作为增强心脏功能的新型有效治疗靶点的潜在用途。cfDNA 在表型上可以作为间质纤维化、心肌细胞收缩功能障碍和细胞死亡等病理过程上调的关键参与者相关。在此，我们回顾了 cfDNA 与心力衰竭的关联，并分析了它们作为增强心脏功能的新型有效治疗靶点的潜在用途。