Sleep and Breathing ( IF 2.1 ) Pub Date : 2022-08-31 , DOI: 10.1007/s11325-022-02701-3 Carlos Alberto Nigro 1 , Ignacio Bledel 1 , Eduardo Borsini 2
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Purpose
To assess the relationship between hypoxemia during polysomnography (PSG) and patient-reported night sweats (NS).
Methods
This retrospective observational study included adult patients who completed a standardized sleep questionnaire and the Epworth Sleepiness Scale (ESS) before PSG.
Results
We included 1397 patients (41% women). The median age was 52 years, 80% had obstructive sleep apnea (OSA) defined as an apnea–hypopnea index (AHI) ≥ 5, and 35% were obese. A total of 245 patients (17.5%) reported NS. Their prevalence was higher among patients with OSA compared to controls (18.9% vs. 12.2%, p < 0.01). In the bivariate analysis, the variables associated with NS were BMI, AHI, hypoxemia (T90 ≥ 2.5% of total recording time plus minimum SO2 < 85%), frequent body movements or awakenings, nightmares, excessive daytime sleepiness (Epworth > 10), nocturia, cardiovascular events, and the use of sedatives or antidepressants. In the multivariate model, the independent predictors of NS were BMI (OR: 1.47, CI 95%: 1.07–2.01, p = 0.016), hypoxemia (OR: 1.87, CI 95%: 1.37–2.60, p = 0.0001), nightmares (OR: 2.60, CI 95%: 1.73–3.80, p < 0.0001), frequent body movements and awakenings (OR: 1.57, CI 95%: 1.16–2.11, p = 0.003 and OR: 1.54, CI 95%: 1.13–2.08, p = 0.005, respectively), and excessive daytime sleepiness (OR: 1.65, CI 95%: 1.24–2.20, p = 0.0007).
Conclusions
In patients with OSA, night sweats were significantly and independently associated with a higher hypoxic burden.
中文翻译：
阻塞性睡眠呼吸暂停患者低氧血症和盗汗之间的独立关联
目的
评估多导睡眠图 (PSG) 期间的低氧血症与患者报告的盗汗 (NS) 之间的关系。
方法
这项回顾性观察研究包括在 PSG 前完成标准化睡眠问卷调查和 Epworth 嗜睡量表 (ESS) 的成年患者。
结果
我们纳入了 1397 名患者（41% 为女性）。中位年龄为 52 岁，80% 患有阻塞性睡眠呼吸暂停 (OSA)，定义为呼吸暂停低通气指数 (AHI) ≥ 5，35% 肥胖。共有 245 名患者 (17.5%) 报告了 NS。与对照组相比，OSA 患者的患病率更高（18.9% 对 12.2%，p < 0.01）。在双变量分析中，与 NS 相关的变量是 BMI、AHI、低氧血症（T90 ≥ 总记录时间的 2.5% 加上最小 SO 2 < 85%）、频繁的身体运动或觉醒、噩梦、白天过度嗜睡（Epworth > 10） 、夜尿、心血管事件以及镇静剂或抗抑郁药的使用。在多变量模型中，NS 的独立预测因子是 BMI（OR：1.47，CI 95%：1.07–2.01，p = 0.016），低氧血症（OR：1.87，CI 95%：1.37-2.60，p = 0.0001），噩梦（OR：2.60，CI 95%：1.73-3.80，p < 0.0001），频繁的身体运动和觉醒（OR： 1.57，CI 95%：1.16-2.11，p = 0.003 和 OR：1.54，CI 95%：1.13-2.08，p = 0.005，分别），以及白天过度嗜睡（OR：1.65，CI 95%：1.24-2.20，p = 0.0007）。
结论
在 OSA 患者中，盗汗与较高的缺氧负荷显着且独立相关。
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