Further studies are required to investigate the impact of the COVID-19 pandemic on Parkinson’s disease (PD) progression. This study investigated the motor and non-motor progression of people with PD (PWP) at 6 months during the COVID-19 pandemic compared with that during the pre-pandemic period. Patients were recruited from Ain Shams University Hospitals, Cairo, in the period between April 2019 and December 2020. Fifty patients were included, of whom 17 and 33 patients were followed for 6 months before and during the pandemic, respectively. All patients were assessed at baseline and at 6 months using the MDS-UPDRS, Schwab and England scale (S&E), Hoehn and Yahr scale (H&Y), Berg Balance Scale, Timed Up and Go test (TUG), International Physical Activity Questionnaire, New Freezing of Gait Questionnaire, Non-Motor Symptoms Scale, and Beck Depression Inventory (BDI). Both groups were matched in age, gender, and disease characteristics. Patients followed during the pandemic showed more significant worsening of the total, part I and motor part of MDS-UPDRS, and balance scores (p < 0.001) than those followed during the pre-COVID-19 period. Gait (TUG), balance, and physical activity worsening were significantly correlated with baseline BDI, gait and balance scores, total and part I MDS-UPDRS scores, H&Y, and S&E OFF scores. Gait deterioration (TUG) was correlated with baseline physical activity (r = −0.510, p = 0.002). PWP showed worsening of motor and non-motor symptoms during the COVID-19 pandemic at the 6-month follow-up. Worsening of gait, balance, and physical activity was correlated with baseline motor and physical activity OFF scores.

需要进一步研究来调查 COVID-19 大流行对帕金森病 (PD) 进展的影响。本研究调查了与大流行前相比，在 COVID-19 大流行期间 6 个月时 PD (PWP) 患者的运动和非运动进展。患者于 2019 年 4 月至 2020 年 12 月期间从开罗 Ain Shams 大学医院招募。包括 50 名患者，其中 17 名和 33 名患者分别在大流行前和大流行期间随访了 6 个月。所有患者在基线和 6 个月时使用 MDS-UPDRS、Schwab 和 England 量表 (S&E)、Hoehn 和 Yahr 量表 (H&Y)、Berg 平衡量表、Timed Up and Go 测试 (TUG)、国际体育活动问卷、新的冻结步态问卷、非运动症状量表、和贝克抑郁量表（BDI）。两组在年龄、性别和疾病特征上均匹配。在大流行期间跟踪的患者显示 MDS-UPDRS 的总分、第一部分和运动部分以及平衡评分更显着恶化。p  < 0.001）比在 COVID-19 之前的时期所遵循的。步态 (TUG)、平衡和身体活动恶化与基线 BDI、步态和平衡评分、总和部分 I MDS-UPDRS 评分、H&Y 和 S&E OFF 评分显着相关。步态恶化 (TUG) 与基线身体活动相关 ( r  = -0.510, p  = 0.002)。在 6 个月的随访中，PWP 显示在 COVID-19 大流行期间运动和非运动症状恶化。步态、平衡和身体活动的恶化与基线运动和身体活动 OFF 分数相关。