Di-(2-ethylhexyl) phthalate (DEHP) is the world's most widely used polyvinyl chloride (PVC) plasticizer and is used in virtually every category of flexible PVC. In fact, DEHP is extensively used in food cosmetics and medical packaging. It has become a serious problem in recent years. DEHP can be absorbed into the human body through the air, food, water, and skin. The current study involved intraperitoneal injection of DEHP dissolved in corn oil once daily for 21 consecutive days to investigate the effects of DEHP on the thyroid and the reproductive system in female rats. Results show that ovarian hormones (progesterone and estrogen) decreased significantly in the rats treated with DEHP compared to control. This result is supported by the alteration of folliculogenesis, the decrease of the follicles viability, and the apoptosis of the granulosa cells observed on histological sections of ovary and thyroid in female rats exposed to low doses of DEHP. Histopathological study revealed that DEHP could damage thyroid tissue and disrupt these functions. We also observed cellular damage, particularly in the liver cells, and a significant increase in biochemical parameters such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared to the control group.

邻苯二甲酸二（2-乙基己基）酯 (DEHP) 是世界上使用最广泛的聚氯乙烯 (PVC) 增塑剂，几乎用于所有类别的软质 PVC。事实上，DEHP 广泛用于食品化妆品和医疗包装。近年来，它已成为一个严重的问题。DEHP 可通过空气、食物、水和皮肤被人体吸收。目前的研究涉及连续 21 天每天一次腹腔注射溶解在玉米油中的 DEHP，以研究 DEHP 对雌性大鼠甲状腺和生殖系统的影响。结果表明，与对照组相比，用 DEHP 治疗的大鼠的卵巢激素（黄体酮和雌激素）显着降低。这一结果得到了卵泡发生改变、卵泡活力降低、在暴露于低剂量 DEHP 的雌性大鼠的卵巢和甲状腺组织切片上观察到颗粒细胞的凋亡。组织病理学研究表明，DEHP 会损害甲状腺组织并破坏这些功能。我们还观察到细胞损伤，特别是在肝细胞中，与对照组相比，丙氨酸氨基转移酶 (ALT) 和天冬氨酸氨基转移酶 (AST) 等生化参数显着增加。