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Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates
ChemMedChem ( IF 3.6 ) Pub Date : 2022-08-30 , DOI: 10.1002/cmdc.202200444
Sanam Maikoo 1 , Bheki Xulu 1 , Allen Mambanda 1 , Ntando Mkhwanazi 2 , Candace Davison 2 , Jo-Anne de la Mare 2 , Irvin Noel Booysen 1
Affiliation  

Thiosemicarbazone or benzothiazole Schiff base ruthenium compounds were found to display higher anticancer activities against HeLa cervical, HCC70 triple-negative breast, and MCF-7 hormone-responsive breast cancer cells than against MCF-12 A benign cells. DNA interaction studies showed that these octahedral metal complexes are partial DNA intercalators. These metal complexes illustrated optimal BSA uptake with preferential binding to BSA site I.

中文翻译:


细胞毒性钌化合物与缩氨基硫脲或苯并噻唑席夫碱螯合物的生物分子相互作用



研究发现,缩氨基硫脲或苯并噻唑希夫碱钌化合物对 HeLa 宫颈癌、HCC70 三阴性乳腺癌和 MCF-7 激素反应性乳腺癌细胞的抗癌活性高于对 MCF-12 A 良性细胞的抗癌活性。 DNA相互作用研究表明这些八面体金属配合物是部分DNA嵌入剂。这些金属配合物显示出最佳的 BSA 摄取,并优先结合 BSA 位点 I。
更新日期:2022-08-30
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