Lacking osseointegration and peri-implantitis induced by bacterial infiltration are the pivotal issues for the long-term clinical success of implants. In order to improve the bioactivity and antibacterial properties of implant materials, volcano-shaped microporous TiO₂ coatings doped with Zinc (Zn) were fabricated via a micro-arc oxidation (MAO) method on pure titanium (Ti). The microstructure, morphology, and chemical composition of the Zn-doped coatings were systematically studied. In cell culture tests, the formed coatings promoted the adhesion and proliferation of bone mesenchymal stem cells (BMSCs), exhibiting good biocompatibility. The antibacterial experiments revealed that Zn-TiO₂ coatings possess excellent antibacterial properties against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis).

中文翻译：

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植入物用Zn掺杂TiO2涂层的抗菌活性和生物活性

细菌浸润引起的骨整合不足和种植体周围炎是种植体长期临床成功的关键问题。为提高植入材料的生物活性和抗菌性能，采用微弧氧化（MAO）法在纯钛（Ti）上制备了火山形掺杂锌（Zn）的微孔TiO _2涂层。系统地研究了锌掺杂涂层的微观结构、形貌和化学成分。在细胞培养试验中，形成的涂层促进了骨间充质干细胞（BMSCs）的粘附和增殖，表现出良好的生物相容性。抗菌实验表明，Zn-TiO ₂涂层对金黄色葡萄球菌具有优异的抗菌性能（金黄色葡萄球菌）和牙龈卟啉单胞菌（牙龈卟啉单胞菌）。