Objective. The aim of the study is to explore the curative effect of Yangxin Dingji capsule combined with mexiletine hydrochloride on postoperative ventricular arrhythmia (VA) and its influences on vascular endothelial function in coronary bifurcation lesions (CBL). Methods. A total of 110 patients with CBL admitted to the hospital were enrolled as research subjects between January and December 2021. According to the random number table method, they were divided into a combination group and control group, with 55 cases in each group. The control group was treated with mexiletine hydrochloride, while the combination group was additionally treated with Yangxin Dingji capsules. All were continuously treated for 4 weeks. The clinical response rate between the two groups was compared. The frequencies of 24 h paroxysmal atrial fibrillation, premature atrial contraction, and premature ventricular contraction were compared by the Holter monitoring. The whole blood low-shear viscosity, whole blood high-shear viscosity, and fibrinogen (Fb) in both groups were measured by a full-automatic blood flow analyzer. The levels of plasma nitric oxide (NO), endothelin-1 (ET-1), and von Willebrand factor (vWF) were detected by the nitrate reductase method and enzyme-linked immunosorbent assay (ELISA). During treatment, the occurrence of adverse reactions (vomiting, loss of appetite, dry mouth, diarrhea, nausea) in both groups was statistically analyzed. Results. After treatment, the total response rate of treatment in the combination group was significantly higher than that in the control group (). After treatment, frequencies of paroxysmal atrial fibrillation, premature atrial contraction, and premature ventricular contraction in the combination group were significantly lower than those in the control group (). Whole blood low-shear viscosity, whole blood high-shear viscosity, and the Fb level were significantly lower than those in the control group (). After treatment, the NO level in the combination group was significantly higher than that in the control group (), while levels of ET-1 and vWF were significantly lower than those in the control group (). During treatment, there was no significant difference in the total incidence of adverse reactions between the two groups (). Conclusion. Yangxin Dingji capsule combined with mexiletine hydrochloride can significantly improve clinical effects in CBL patients, improve VA and vascular endothelial function, and reduce plasma viscosity without increasing the incidence of adverse reactions.

中文翻译：

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养心定济胶囊联合盐酸美西律对冠状动脉分叉病变术后心律失常的疗效及对血管内皮功能的影响

客观。本研究旨在探讨养心定济胶囊联合盐酸美西律治疗术后室性心律失常(VA)的疗效及其对冠状动脉分叉病变(CBL)血管内皮功能的影响。方法. 2021年1月至2021年12月共纳入我院收治的CBL患者110例作为研究对象，按照随机数字表法分为联合组和对照组，每组55例。对照组加用盐酸美西律治疗，联合组加用养心定济胶囊。全部连续治疗4周。比较两组的临床反应率。通过Holter监测比较24 h阵发性心房颤动、心房早搏和室性早搏的频率。采用全自动血流分析仪测量两组全血低剪切粘度、全血高剪切粘度和纤维蛋白原（Fb）。采用硝酸还原酶法和酶联免疫吸附试验（ELISA）检测血浆一氧化氮（NO）、内皮素-1（ET-1）和血管性血友病因子（vWF）水平。统计分析两组治疗期间不良反应（呕吐、食欲不振、口干、腹泻、恶心）的发生情况。结果。治疗后，联合组治疗总有效率显着高于对照组（）。治疗后，联合组阵发性房颤、房性早搏、室性早搏发生率均显着低于对照组。）。全血低剪切粘度、全血高剪切粘度、Fb水平显着低于对照组（）。治疗后，联合组NO水平明显高于对照组（)，而 ET-1 和 vWF 水平显着低于对照组 (）。治疗期间，两组不良反应总发生率差异无统计学意义（）。 结论。养心定济胶囊联合盐酸美西律可显着改善CBL患者的临床疗效，改善VA和血管内皮功能，降低血浆粘度，且不增加不良反应发生率。