This review article surveys synthetic approaches towards fluorinated cycloalkyl building blocks for drug discovery, their key physicochemical properties, and applications in medicinal chemistry. Examples of successful biologically active derivatives (including marketed drugs) are given, with focus on the role of the fluorinated cycloalkyl substituent in their design.

中文翻译：

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用于药物发现的氟化环烷基结构单元

这篇评论文章调查了用于药物发现的氟化环烷基结构单元的合成方法、它们的关键物理化学性质以及在药物化学中的应用。给出了成功的生物活性衍生物（包括上市药物）的例子，重点是氟化环烷基取代基在其设计中的作用。