Periodontitis is a chronic infectious disease caused by dysbiosis of oral microbiota, ultimately leading to periodontal alveolar bone loss. The oral subgingival microbiome, a key role in periodontitis pathogenesis, could alter the composition of gut microbiomes resulting in intestinal microbiota disorder. D-mannose plays an important role in glucose metabolism; whether it is beneficial to prevention and treatment of periodontitis and the regulation of oral and intestinal microbiota changes is still unknown.

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D-mannose alleviated alveolar bone loss in mice with experimental periodontitis via regulating the anti-inflammatory effect of amino acids,D-甘露糖通过调节氨基酸的抗炎作用减轻实验性牙周炎小鼠的牙槽骨丢失

Periodontitis is a chronic infectious disease caused by dysbiosis of oral microbiota, ultimately leading to periodontal alveolar bone loss. The oral subgingival microbiome, a key role in periodontitis pathogenesis, could alter the composition of gut microbiomes resulting in intestinal microbiota disorder. D-mannose plays an important role in glucose metabolism; whether it is beneficial to prevention and treatment of periodontitis and the regulation of oral and intestinal microbiota changes is still unknown.,牙周炎是一种由口腔微生物群失调引起的慢性感染性疾病，最终导致牙周牙槽骨流失。口腔龈下微生物群在牙周炎发病机制中发挥着关键作用，可能会改变肠道微生物群的组成，导致肠道微生物群紊乱。D-甘露糖在葡萄糖代谢中发挥重要作用；是否有利于牙周炎的防治以及口腔和肠道菌群变化的调节尚不清楚。