A New Approach toward the Realization of Specific and Label-Free Biological Sensing Based on Field-Effect Devices,Advanced Electronic Materials

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A New Approach toward the Realization of Specific and Label-Free Biological Sensing Based on Field-Effect Devices
Advanced Electronic Materials ( IF 5.3 ) Pub Date : 2022-08-28 , DOI: 10.1002/aelm.202200399
Ie Mei Bhattacharyya ₁ , Izhar Ron ₁ , Ruth Shima‐Edelstein ₂ , Evgeny Pikhay ₂ , Yakov Roizin ₂ , Gil Shalev _{1,

3}

Affiliation

Specific and label-free detection of biological interactions is paramount to a plethora of technological applications ranging from home-care diagnostics to smart agriculture and home security. The biologically-modified field-effect transistor (BioFET) is a promising sensing platform due to its inherent signal amplification, low power, and miniaturization. In the following a low-cost meta-nano-channel BioFET (MNC BioFET) is reported that provides means to electrostatically control the size, shape, and location of the conducting channel such as to enhance the coupling between the locally-occurring electrostatics of the biological interactions and the electrodynamics of the underlying conducting channel. Moreover, it provides means to electrostatically control the Debye screening length at the sensing area to increase the readout signal. The MNC BioFET is fabricated in a large-scale silicon chip foundry that ensures robustness and stability, optimal noise levels and signal amplification, repeatability, and ultimate miniaturization with the potential for high-end multiplexing in ultra-small samples. In the current study, a specific and label-free sensing of prostate specific antigen with the MNC BioFET is demonstrated, and show the dependency of the sensor signal on the channel configuration. Finally, an order of magnitude enhancement in readout signal is demonstrated by the electrostatic control of the screening length at the sensing area.

中文翻译：

基于场效应器件实现特异性无标记生物传感的新途径

生物相互作用的特异性和无标记检测对于从家庭护理诊断到智能农业和家庭安全等众多技术应用至关重要。由于其固有的信号放大、低功耗和小型化，生物修饰的场效应晶体管 (BioFET) 是一个很有前途的传感平台。在下文中，报道了一种低成本的超纳米通道 BioFET (MNC BioFET)，它提供了静电控制导电通道的大小、形状和位置的方法，例如增强局部发生的静电之间的耦合。生物相互作用和底层传导通道的电动力学。此外，它提供了静电控制感测区域的德拜屏蔽长度以增加读出信号的方法。MNC BioFET 在大型硅芯片铸造厂制造，可确保稳健性和稳定性、最佳噪声水平和信号放大、可重复性和最终小型化，并具有在超小样本中进行高端多路复用的潜力。在当前的研究中，演示了使用 MNC BioFET 对前列腺特异性抗原进行特异性和无标记检测，并显示了传感器信号对通道配置的依赖性。最后，通过感应区域屏蔽长度的静电控制，证明了读出信号的数量级增强。和最终的小型化，具有在超小样本中进行高端多重分析的潜力。在当前的研究中，演示了使用 MNC BioFET 对前列腺特异性抗原进行特异性和无标记检测，并显示了传感器信号对通道配置的依赖性。最后，通过感应区域屏蔽长度的静电控制，证明了读出信号的数量级增强。和最终的小型化，具有在超小样本中进行高端多重分析的潜力。在当前的研究中，演示了使用 MNC BioFET 对前列腺特异性抗原进行特异性和无标记检测，并显示了传感器信号对通道配置的依赖性。最后，通过感应区域屏蔽长度的静电控制，证明了读出信号的数量级增强。

更新日期：2022-08-28

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