RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease,Hepatology

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RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology ( IF 13.5 ) Pub Date : 2022-08-27 , DOI: 10.1002/hep.32756
Marta B Afonso ₁ , Tawhidul Islam ₁ , Julie Magusto _{2,

3} , Ricardo Amorim ₄ , Véronique Lenoir ₅ , Rui F Simões ₄ , José Teixeira ₄ , Liana C Silva ₁ , Dominique Wendum _{3,

6} , Isabelle Jéru _{2,

3,

7} , Corinne Vigouroux _{2,

3,

8} , Rui E Castro ₁ , Paulo J Oliveira ₄ , Carina Prip-Buus ₅ , Vlad Ratziu _{2,

9,

10} , Jérémie Gautheron _{2,

3} , Cecília M P Rodrigues ₁

Affiliation

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy , Universidade de Lisboa , Lisbon , Portugal.
Institute of Cardiometabolism and Nutrition , Paris , France.
Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine , Paris , France.
CNC - Center for Neuroscience and Cell Biology , University of Coimbra , Coimbra , Portugal.
Université de Paris, Institut Cochin, INSERM, CNRS , Paris , France.
Service d'Anatomo-Pathologie, Service d'Hépatologie , Centre de Référence Maladie Rare Maladies Inflammatoires des Voies Biliaires-Hépatites Auto-immunes , Paris , France.
Laboratoire commun de Biologie et Génétique Moléculaires , Hôpital Saint-Antoine , Paris , France.
Centre National de Référence des Pathologies Rares de l'Insulino-Sécrétion et de l'Insulino-Sensibilité, Service de Diabétologie et Endocrinologie de la Reproduction , Hôpital Saint-Antoine , Paris , France.
Department of Hepatology , Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital , Paris , France.
Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, and ICAN Institute of Cardiometabolism and Nutrition , Paris , France.

Receptor-interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD) architecture in NAFLD.

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