Abstract

The primary objective of this study was to examine if people with protein C deficiency, which is a natural anticoagulant and also an endogenous acyl ghrelin peptidase, have elevated circulating levels of acyl ghrelin. The clinical trial was conducted in a university hospital setting. People with protein C deficiency were identified and invited to participate by a specialized coagulation outpatient clinic. People with protein C deficiency were examined and compared to age, sex, and body mass index matched healthy controls with regards to acyl ghrelin, unacylated ghrelin, growth hormone (GH) and insulin-like growth-factor I (IGF-I) in a cross-sectional case-control study. Systemic levels of acyl ghrelin, desacyl ghrelin, acyl-to-desacyl ghrelin ratio, GH and IGF-I were similar in people with protein C deficiency and healthy controls. Despite a significant reduction of protein C in people with protein C deficiency, there was no difference in acyl ghrelin or the secondary end points unacylated ghrelin, GH, or IGF-I in people with protein C deficiency.

摘要

本研究的主要目的是检查蛋白 C 缺乏症患者（一种天然抗凝剂和内源性酰基生长素释放肽酶）是否具有升高的酰基生长素释放肽循环水平。临床试验是在大学医院环境中进行的。蛋白质 C 缺乏症患者被专门的凝血门诊所识别并邀请参加。对蛋白质 C 缺乏的人进行了检查，并与年龄、性别和体重指数匹配的健康对照组进行了比较，其中包括酰基生长素释放肽、未酰化生长素释放肽、生长激素 (GH) 和胰岛素样生长因子 I (IGF-I)横断面病例对照研究。在蛋白质 C 缺乏症患者和健康对照者中，酰基生长素释放肽、脱酰基生长素释放肽、酰基与脱酰基生长素释放肽比率、GH 和 IGF-I 的全身水平相似。