Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.

补充肌酸 (Cr) 是一种行之有效的策略，可以增强阻力训练期间的力量、瘦体重和爆发力。然而，肌酰-L-亮氨酸 (CLL)（一种所谓的 Cr 酰胺）的有效性尚不清楚。因此，本研究的目的是评估 CLL 对肌肉 Cr 含量的影响。29 名健康男性 ( n  = 17) 和女性 ( n  = 12) 每天摄入 5 克一水合铬 ( n  = 8; 28.5 ± 7.3 岁, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL ( n = 8 )  = 11；29.2 ± 9.3 岁，170.3 ± 10.5 厘米，71.9 ± 14.5 公斤），或安慰剂（n = 10；30.3 ± 6.9 岁，167.8 ± 9.9 厘米，69.9 ± 11.1 公斤），持续 14 天，采用随机双盲设计。参与者每周完成三轮监督阻力运动。在干预前后收集肌肉活检以定量肌肉 Cr。一水合铬补充剂在补充 14 天后显着增加了肌肉铬含量。安慰剂组或 CLL 组没有观察到肌肉 Cr 的变化。补充一水铬是增加肌肉铬含量的有效策略，而慢性淋巴细胞白血病则不然。