Is intervertebral disc degeneration associated with reduction in serum ferritin?,European Spine Journal

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Is intervertebral disc degeneration associated with reduction in serum ferritin?
European Spine Journal ( IF 2.6 ) Pub Date : 2022-08-25 , DOI: 10.1007/s00586-022-07361-1
Youfeng Guo ₁ , Chao Li ₂ , Beiduo Shen ₁ , Xianzhen Chen ₂ , Tao Hu ₁ , Desheng Wu ₁

Affiliation

Objective

Ferritin autophagy is characterized by intracellular ferroptosis and selective ferritin degradation. However, the role of ferritin in the development of intervertebral disc degeneration (IDD) has not been elucidated. The study aimed to investigate the role of serum iron metabolism markers, especially serum ferritin (SF), in IDD.

Methods

217 patients who came to the spine surgery department of our hospital for low back pain were recruited, and blood samples were collected for routine examination after admission. The cumulative grade was also calculated by summing up the Pfirrmann grade of all lumbar discs.

Results

Correlation analysis showed that cumulative grade was correlated with SF (r = − 0.185, p = 0.006), not with serum iron (SI), transferrin saturation (TS), unsaturated iron-binding capacity (UIBC) and total iron-binding capacity (TIBC) (all p > 0.05). In addition, SF levels in the low severity IDD were significantly higher than high severity IDD in cumulative grade (p = 0.003) and single disc grade. No statistically significant difference was found in the other four indicators. A statistically significant difference was observed between the high (cumulative grade > 17) and low score (cumulative grade ≤ 17) groups in terms of age. According to the ROC curve, the cut-off value of SF levels was 170.5. Patients with SF < 170.5 ng/mL had severe disc degeneration. The sensitivity and specificity were 0.635 and 0.602, respectively.

Conclusion

This study preliminarily showed that SF was negatively correlated with the degree of IDD and can be used to predict IDD severity.

中文翻译：

椎间盘退变与血清铁蛋白降低有关吗？

客观的

铁蛋白自噬的特征是细胞内铁死亡和选择性铁蛋白降解。然而，铁蛋白在椎间盘退变（IDD）发展中的作用尚未阐明。该研究旨在探讨血清铁代谢标志物，特别是血清铁蛋白（SF）在 IDD 中的作用。

方法

纳入因腰痛来我院脊柱外科就诊的患者217例，入院后采集血样进行常规检查。累积等级也是通过将所有腰椎间盘的 Pfirrmann 等级相加来计算的。

结果

相关分析显示，累积等级与 SF 相关（r = − 0.185，p = 0.006），而与血清铁（SI）、转铁蛋白饱和度（TS）、不饱和铁结合力（UIBC）和总铁结合力（ TIBC）（所有p > 0.05）。此外，在累积分级 ( p = 0.003) 和单椎间盘分级中，低严重性 IDD 中的 SF 水平显着高于高严重性 IDD 。其他四项指标均无统计学差异。高分组（累计成绩>17分）和低分组（累计成绩≤17分）在年龄上存在统计学差异。根据ROC曲线，SF水平的截止值为170.5。SF < 170.5 ng/mL 的患者患有严重的椎间盘退变。敏感性和特异性分别为 0.635 和 0.602。