An efficient multicomponent sequential process, which occurs in mild condition has been exploited for the synthesis of systematically modified amphiphilic molecules where the cationic head is tethered to a lipophilic tail through a dihydroorotic acid linker. The process is operatively simple, high yielding, and flexible. Such a strategy could impact combinatorial synthesis of wide libraries of amphiphilic molecules to be tested as transfection agents and/or as antimicrobials.

中文翻译：

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基于二氢乳清酸的两亲分子的多组分顺序合成

一种在温和条件下发生的有效的多组分顺序过程已被用于合成系统修饰的两亲分子，其中阳离子头通过二氢乳清酸接头连接到亲脂尾部。该工艺操作简单、产率高且灵活。这种策略可能会影响广泛的两亲分子文库的组合合成，以作为转染剂和/或抗菌剂进行测试。