The goal of this study was to examine associations between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality by a genetic risk score (GRS) for longevity. Among 5,446 women, (mean [SD]: age, 78.2 [6.6] years), 1,022 deaths were observed during 33,350 person-years of follow-up. Using multivariable Cox proportional hazards models, higher light PA and moderate to vigorous PA were associated with lower mortality across all GRS for longevity categories (low/medium/high; all p_trend < .001). Higher ST was associated with higher mortality (p_trend across all GRS categories < .001). Interaction tests for PA and ST with the GRS were not statistically significant. Findings support the importance of higher PA and lower ST for reducing mortality risk in older women, regardless of genetic predisposition for longevity.

本研究的目的是通过长寿遗传风险评分 (GRS) 来检查加速度计测量的体力活动 (PA) 和久坐时间 (ST) 与死亡率之间的关系。在 5,446 名女性（平均 [ SD ]：年龄，78.2 [6.6] 岁）中，在 33,350 人年的随访期间观察到 1,022 人死亡。使用多变量 Cox 比例风险模型，较高的轻度 PA 和中度至剧烈 PA 与所有 GRS 长寿类别的较低死亡率相关（低/中/高；所有p_趋势< .001）。较高的 ST 与较高的死亡率相关（所有 GRS 类别的p_趋势< .001）。 PA 和 ST 与 GRS 的相互作用测试没有统计学意义。研究结果支持较高的 PA 和较低的 ST 对于降低老年女性死亡风险的重要性，无论长寿的遗传倾向如何。