Background The identification of biomarkers and other mechanisms for early detection of Alzheimer’s disease is critical to the development and further advancement of therapies and interventions targeted at managing symptoms and tracking the pathophysiology of disease. The endorsement of subjective cognitive decline (SCD) has emerged as a potential indicator of early change in cognitive status that may be predictive of future impairment at a time when measurable declines in neuropsychological performance cannot be detected. While there are numerous findings revealing sex differences in the prevalence of Alzheimer’s disease, there is a paucity of research examining sex differences in SCD. Therefore, the goal of this project is to determine if the relationship between the endorsement of SCD and future cognitive changes differ as a function of biological sex.

中文翻译：

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与男性相比，主观认知衰退是女性未来认知衰退的更好标志

背景识别用于早期检测阿尔茨海默病的生物标志物和其他机制对于开发和进一步推进旨在管理症状和追踪疾病病理生理学的疗法和干预措施至关重要。对主观认知能力下降 (SCD) 的认可已成为认知状态早期变化的潜在指标，在无法检测到神经心理表现的可测量下降时，这可能预示着未来的损害。虽然有许多发现揭示了阿尔茨海默病患病率的性别差异，但很少有研究检查 SCD 的性别差异。因此，该项目的目标是确定 SCD 的认可与未来认知变化之间的关系是否因生理性别而异。