We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO₂max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO₂max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or placebo supplementation for a total of 6 months. The participants underwent exercise testing and clinical investigations at baseline, 3 months, and 6 months. Main study endpoint was change in VO₂max from baseline to 6 months. Fifty-eight participants completed the 6-month test and were included in the final data analysis (age: Calanus, 39.7 [38.0, 41.4] and placebo, 38.8 [36.8, 40.9] years; body mass index: Calanus, 24.8 [24.0, 25.6] and placebo, 24.8 [23.7, 25.8] kg/m²; and VO₂max: Calanus, 50.4 [47.1, 53.8] and placebo, 50.2 [47.2, 53.1] ml·kg⁻¹·min⁻¹). There were no between-group differences at baseline, nor were there any between-group differences in absolute (Calanus, 3.74 [3.44, 4.04] and placebo, 3.79 [3.44, 4.14] L/min) or relative VO₂max (Calanus, 49.7 [46.2, 53.2] and placebo, 49.5 [46.0, 53.1] ml·kg⁻¹·min⁻¹) at 6 months (mean [95% confidence interval]). There were no between-groups change in clinical measures from baseline to 3 and 6 months. In conclusion, VO₂max was unaffected by 6 months of daily Calanus oil supplementation in healthy, physically fit, normal to overweight men and women between 30 and 50 years old.

我们旨在研究每日补充 Calanus 油对30 至 50 岁健康参与者的最大摄氧量 (VO ₂ max)的长期影响。该研究的动机是临床前研究报告增加了 VO ₂ max 和富含 omega-3 的 Calanus 油的代谢健康。在一项双盲研究中，71 名参与者被随机分配接受 2 克/天的 Calanus 或安慰剂补充剂，共 6 个月。参与者在基线、3 个月和 6 个月时接受了运动测试和临床调查。主要研究终点是 VO _2的变化最长从基线到 6 个月。58 名参与者完成了为期 6 个月的测试并被纳入最终数据分析（年龄：Clanus，39.7 [38.0, 41.4] 和安慰剂，38.8 [36.8, 40.9] 岁；体重指数：Clanus，24.8 [24.0, 25.6]和安慰剂，24.8 [23.7, 25.8] kg/m ²；和VO ₂ max：Calanus，50.4 [47.1, 53.8]和安慰剂，50.2 [47.2, 53.1] ml·kg ^-1 ·min ^-1 )。基线时没有组间差异，绝对（Calanus，3.74 [3.44, 4.04] 和安慰剂，3.79 [3.44, 4.14] L/min）或相对 VO ₂ max（Calanus， 49.7 [46.2, 53.2] 和安慰剂，49.5 [46.0, 53.1] ml·kg ^-1 ·min ^-1) 在 6 个月时（平均 [95% 置信区间]）。从基线到 3 个月和 6 个月的临床测量没有组间变化。总之，在 30 至 50 岁的健康、身体健康、正常至超重的男性和女性中，每天补充 6 个月的 Calanus 油不会影响VO _{2 max。}