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Mesoporous Polydopamine-Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor-Sufficient Synergistic Therapy
ChemMedChem ( IF 3.4 ) Pub Date : 2022-08-24 , DOI: 10.1002/cmdc.202200360
Suhua Jiang, Fukai Zhu, Xiaoxuan Ji, Jiaqi Li, Haina Tian, Bingli Wang, Luanmei Lu, Peiyuan Wang

We used a versatile method to construct mesoporous polydopamine nanovehicles (MPDA) with the dendritic mesopores loaded with a clinical chemotherapeutic drug, doxorubicin (MPDA@DOX). The MPDA delivery platform has a precise tumor-targeting effect; in vivo tumor ablation experiments revealed MPDA@DOX to have markedly tumor growth eradication capacity under laser exposure.

中文翻译:

基于介孔聚多巴胺的纳米载体作为多功能药物装载平台以实现肿瘤充足的协同治疗

我们使用一种通用的方法来构建介孔聚多巴胺纳米载体 (MPDA),其树突状介孔装载有临床化疗药物多柔比星 (MPDA@DOX)。MPDA递送平台具有精准的肿瘤靶向作用;体内肿瘤消融实验表明 MPDA@DOX 在激光照射下具有显着的肿瘤生长根除能力。
更新日期:2022-08-24
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