Cocaine use results in over 500,000 emergency department (ED) visits annually across the United States and ethanol co-ingestion is reported in 34% of these. Commingling cocaine with ethanol results in the metabolite cocaethylene (CE), which is metabolically active for longer than cocaine alone. Current literature on the cardiotoxicity of CE compared to cocaine alone is limited and lacks consensus. This study aims to fill this gap in the literature and examine cardiovascular events in cocaine use as confirmed by urine toxicology versus CE exposure.

中文翻译：

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急诊科急性药物过量患者的可卡乙烯心脏毒性


美国每年有超过 500,000 人因吸食可卡因而到急诊室 (ED) 就诊，其中 34% 的人同时摄入乙醇。将可卡因与乙醇混合会产生代谢物可卡乙烯 (CE)，其代谢活性比单独可卡因更长。目前关于 CE 与单独使用可卡因相比的心脏毒性的文献有限且缺乏共识。本研究旨在填补文献中的这一空白，并通过尿液毒理学与 CE 暴露证实可卡因使用中的心血管事件。