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Sulfoxide-Containing Polyacrylamides Prepared by PICAR ATRP for Biohybrid Materials
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-08-23 , DOI: 10.1021/acsmacrolett.2c00442 Mateusz Olszewski 1 , Jaepil Jeong 1 , Grzegorz Szczepaniak 1 , Sipei Li 1 , Alan Enciso 1 , Hironobu Murata 1 , Saadyah Averick 2 , Kriti Kapil 1 , Subha R Das 1, 3 , Krzysztof Matyjaszewski 1
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-08-23 , DOI: 10.1021/acsmacrolett.2c00442 Mateusz Olszewski 1 , Jaepil Jeong 1 , Grzegorz Szczepaniak 1 , Sipei Li 1 , Alan Enciso 1 , Hironobu Murata 1 , Saadyah Averick 2 , Kriti Kapil 1 , Subha R Das 1, 3 , Krzysztof Matyjaszewski 1
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Water-soluble and biocompatible polymers are of interest in biomedicine as the search for alternatives to PEG-based materials becomes more important. In this work, the synthesis of a new sulfoxide-containing monomer, 2-(methylsulfinyl)ethyl acrylamide (MSEAM), is reported. Well-defined polymers were prepared by photoinduced initiators for continuous activator regeneration atom transfer radical polymerization (PICAR ATRP). The polymerizations were performed in water under biologically relevant conditions in a small volume without degassing the reaction mixture. DNA-PMSEAM and protein-PMSEAM hybrids were also synthesized. The lower critical solution temperature (LCST) of PMSEAM was estimated to be approximately 170 °C by extrapolating the LCST for a series of copolymers with variable content of N-isopropylacrylamide. The cytotoxicity studies showed excellent biocompatibility of PMSEAM, even at concentrations up to 2.5 mg/mL. Furthermore, the MSEAM monomer exhibited relatively lower toxicity than similar (meth)acrylate-based monomers at comparable concentrations.
中文翻译：
PICAR ATRP 制备的用于生物混合材料的含亚砜聚丙烯酰胺
随着寻找 PEG 基材料的替代品变得越来越重要，水溶性和生物相容性聚合物在生物医学中受到关注。在这项工作中，报道了一种新的含亚砜单体 2-(甲基亚磺酰基) 乙基丙烯酰胺 (MSEAM) 的合成。通过用于连续活化剂再生原子转移自由基聚合 (PICAR ATRP) 的光诱导引发剂制备了定义明确的聚合物。聚合反应是在生物学相关条件下在水中以小体积进行的，反应混合物没有脱气。还合成了 DNA-PMSEAM 和蛋白质-PMSEAM 杂交体。PMSEAM 的下临界溶解温度 (LCST) 通过外推一系列具有可变N含量的共聚物的 LCST 估计约为 170 °C-异丙基丙烯酰胺。细胞毒性研究表明 PMSEAM 具有出色的生物相容性，即使浓度高达 2.5 mg/mL。此外，在可比较的浓度下，MSEAM 单体的毒性低于类似的（甲基）丙烯酸酯基单体。
更新日期：2022-08-23
中文翻译：
PICAR ATRP 制备的用于生物混合材料的含亚砜聚丙烯酰胺
随着寻找 PEG 基材料的替代品变得越来越重要，水溶性和生物相容性聚合物在生物医学中受到关注。在这项工作中，报道了一种新的含亚砜单体 2-(甲基亚磺酰基) 乙基丙烯酰胺 (MSEAM) 的合成。通过用于连续活化剂再生原子转移自由基聚合 (PICAR ATRP) 的光诱导引发剂制备了定义明确的聚合物。聚合反应是在生物学相关条件下在水中以小体积进行的，反应混合物没有脱气。还合成了 DNA-PMSEAM 和蛋白质-PMSEAM 杂交体。PMSEAM 的下临界溶解温度 (LCST) 通过外推一系列具有可变N含量的共聚物的 LCST 估计约为 170 °C-异丙基丙烯酰胺。细胞毒性研究表明 PMSEAM 具有出色的生物相容性，即使浓度高达 2.5 mg/mL。此外，在可比较的浓度下，MSEAM 单体的毒性低于类似的（甲基）丙烯酸酯基单体。
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