All processes involved in metal homeostasis must be coordinated to provide sufficient, but not toxic, concentrations of important bioelements, and to minimize detrimental effects of toxic metals. Our previous studies dealing with the exposure of O. nubilalis non-diapausing larvae to dietary Cd demonstrated that exposure to higher concentrations of Cd caused delay in the development of larvae, induced oxidative stress and also induced defense mechanisms against the toxic effects of Cd. The aim of the present study was to evaluate how acute and chronic exposure of O. nubilalis larvae to increased concentrations of dietary Cd affected the balance of important bioelements. The concentration of bioelements was analyzed in larvae (after short-term exposure) and pupae (after long-term exposure). The short-term exposure of final instar larvae (L5) to Cd did not affect significantly the concentration of any of the analyzed bioelements, while the long-term exposure of developing larvae to higher concentrations of Cd caused increase in the concentrations of Ca, Mg and Na in pupae. The bioaccumulation factor, calculated for bioelements after long-term exposure to Cd, was higher for the most bioelements in groups fed with diet containing higher concentrations of Cd, except K which displayed the opposite trend. Pearson correlation coefficient showed positive correlations between Cd and Ca, Mg, Na, Fe, Cu and Zn, while negative correlation was observed between Cd and K. The results indicate that impact on the balance of important bioelements might be one of the mechanisms of cadmium toxicity and certainly raise numerous questions for future research.

必须协调参与金属稳态的所有过程，以提供足够但无毒的重要生物元素浓度，并将有毒金属的有害影响降至最低。我们之前关于将O. nubilalis非滞育幼虫暴露于膳食 Cd 的研究表明，暴露于较高浓度的 Cd 会导致幼虫发育延迟，诱导氧化应激并诱导针对 Cd 毒性作用的防御机制。本研究的目的是评估如何急性和慢性暴露O. nubilalis幼虫对日粮镉浓度的增加影响了重要生物元素的平衡。分析了幼虫（短期暴露后）和蛹（长期暴露后）中的生物元素浓度。终龄幼虫 (L5) 短期暴露于 Cd 不会显着影响任何分析的生物元素的浓度，而发育中的幼虫长期暴露于较高浓度 Cd 会导致 Ca、Mg 浓度增加和蛹中的钠。在长期暴露于 Cd 后计算的生物元素的生物累积因子在喂食含有较高浓度 Cd 的饮食的组中的大多数生物元素较高，但 K 表现出相反的趋势。Pearson 相关系数显示 Cd 与 Ca、Mg、Na、Fe、Cu 和 Zn 呈正相关，