Aim In this study, we aimed to evaluate serum vitamin D and zinc levels in children diagnosed with coronavirus disease 2019 (COVID-19). Materials and methods In this study, 88 children with COVID-19 disease and 88 healthy children aged 1–18 years were enrolled between 01 July 2021 and 30 October 2021 in the Pediatrics Clinic of Tekirdağ Çorlu State Hospital. Serum vitamin D and zinc levels have been measured and NCSS (Number Cruncher Statistical System) program has been utilized for statistical analysis. Results We included 88 COVID-19 positive pediatric patients [50% (n = 44) female] and 88 healthy children [48.86% (n = 43) female] in this study. The mean serum vitamin D levels of COVID-19 positive patients were statistically significantly lower than the control group (p = 0.0001). The zinc mean values of the study group were found to be statistically significantly lower than the control group (p = 0.0001). There was a statistically significant correlation between serum vitamin D and zinc values in all patient groups (r = 0.245, p = 0.001). Conclusion As a result, zinc and vitamin D levels were observed lower in COVID-19 patients than in healthy individuals. Since there is no defined treatment protocol for COVID-19 infection on children yet, zinc and vitamin D supplementation can be used as a supportive treatment in COVID-19 infection.

中文翻译：

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维生素 D 和锌水平对 COVID-19 阳性儿童免疫反应的临床意义


目的 在本研究中，我们旨在评估诊断为 2019 年冠状病毒病 (COVID-19) 的儿童的血清维生素 D 和锌水平。材料和方法 在本研究中，2021 年 7 月 1 日至 2021 年 10 月 30 日期间，泰基尔达乔尔卢州立医院儿科诊所招募了 88 名患有 COVID-19 疾病的儿童和 88 名 1-18 岁的健康儿童。测量了血清维生素 D 和锌水平，并利用 NCSS（Number Cruncher Statistical System）程序进行统计分析。结果 本研究纳入了 88 名 COVID-19 阳性儿科患者 [50% (n = 44) 女性] 和 88 名健康儿童 [48.86% (n = 43) 女性]。 COVID-19阳性患者的平均血清维生素D水平在统计学上显着低于对照组（p = 0.0001）。研究发现，研究组的锌平均值在统计学上显着低于对照组（p = 0.0001）。所有患者组的血清维生素 D 和锌值之间存在统计学上显着的相关性（r = 0.245，p = 0.001）。结论 因此，观察到 COVID-19 患者的锌和维生素 D 水平低于健康个体。由于儿童 C​​OVID-19 感染尚无明确的治疗方案，因此补充锌和维生素 D 可作为 COVID-19 感染的支持治疗。