As the third most common cause of cancer-related death worldwide with significant mortality rates in the United States, hepatocellular carcinoma has strong association with cirrhosis and chronic hepatitis B virus (HBV) with a growing at-risk population from the rise in chronic liver disease from alcohol use and nonalcoholic fatty liver disease. Despite this, progress in identifying at-risk individuals and early detection of HCC in these populations have lagged behind treatment advances.The lack of consensus may undermine widespread adoption of surveillance programs, thus preventing HCC detection at a curable stage. This public policy corner piece focuses on opportunities for prevention of HCC by focusing on its principal risk factors: viral hepatitis, NAFLD, and alcohol-related liver disease, and three key action points to reverse the course of this public health crisis: 1) Awareness and education; 2) Screening and diagnosis, and 3) Partnerships and advocacy.

中文翻译：

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从根源上解决肝细胞癌的公共卫生危机


肝细胞癌是全球第三大癌症相关死亡原因，在美国死亡率很高，它与肝硬化和慢性乙型肝炎病毒 (HBV) 密切相关，随着慢性肝病的增加，高危人群不断增加因饮酒和非酒精性脂肪肝。尽管如此，在识别高危人群和早期检测这些人群中 HCC 方面的进展仍落后于治疗进展。缺乏共识可能会破坏监测计划的广泛采用，从而阻止 HCC 在可治愈阶段的检测。本公共政策角文章重点关注预防 HCC 的机会，重点关注其主要风险因素：病毒性肝炎、NAFLD 和酒精相关性肝病，以及扭转这一公共卫生危机进程的三个关键行动点：1) 认识和教育； 2) 筛查和诊断，以及 3) 合作和宣传。