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AIF1+CSF1R+ MSCs, induced by TNF-α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis
Hepatology ( IF 12.9 ) Pub Date : 2022-08-21 , DOI: 10.1002/hep.32738
Chen Zong 1, 2 , Yan Meng 1, 2 , Fei Ye 1, 2 , Xue Yang 1, 2 , Rong Li 1 , Jinghua Jiang 1, 2 , Qiudong Zhao 1, 2 , Lu Gao 1, 2 , Zhipeng Han 1, 2 , Lixin Wei 1, 2
Affiliation  

Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver. Chronic inflammation is regarded as the major trait of primary liver cancer. However, the characteristics of endogenous MSCs in the inflammatory environment and their role in the occurrence of liver cancer remain obscure.

中文翻译:

TNF-α诱导的AIF1+CSF1R+ MSCs可产生炎症微环境并促进肝癌发生

越来越多的证据表明,间充质干细胞(MSC)以受损的局部组织和肝脏中的肿瘤微环境为家。慢性炎症被认为是原发性肝癌的主要特征。然而,内源性MSCs在炎症环境中的特性及其在肝癌发生中的作用仍不清楚。
更新日期:2022-08-21
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