Journal of Advanced Research ( IF 11.4 ) Pub Date : 2022-08-21 , DOI: 10.1016/j.jare.2022.08.012 Ruiyang Ding 1 , Xiaoke Ren 1 , Qinglin Sun 1 , Zhiwei Sun 1 , Junchao Duan 1
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Background
Nowadays, cigarette smoking remains the leading cause of chronic disease and premature death, especially cardiovascular disease. As an emerging tobacco product, e-cigarettes have been advocated as alternatives to canonical cigarettes, and thus may be an aid to promote smoking cessation. However, recent studies indicated that e-cigarettes should not be completely harmless to the cardiovascular system.
Aim of Review
This review aimed to build up an integral perspective of cigarettes and e-cigarettes-related cardiovascular toxicity.
Key Scientific Concepts of Review
This review adopted the adverse outcome pathway (AOP) framework as a pivotal tool and aimed to elucidate the association between the molecular initiating events (MIEs) induced by cigarette and e-cigarette exposure to the cardiovascular adverse outcome. Since the excessive generation of reactive oxygen species (ROS) has been widely approved to play a critical role in cigarette smoke-related CVD and may also be involved in e-cigarette-induced toxic effects, the ROS overproduction and subsequent oxidative stress are regarded as essential parts of this framework. As far as we know, this should be the first AOP framework focusing on cigarette and e-cigarette-related cardiovascular toxicity, and we hope our work to be a guide in exploring the biomarkers and novel therapies for cardiovascular injury.
中文翻译：
基于不良结果途径框架的经典卷烟和电子烟相关心血管毒性的整体视角
背景
如今，吸烟仍然是慢性病和过早死亡的主要原因，尤其是心血管疾病。作为一种新兴的烟草产品，电子烟已被提倡作为传统香烟的替代品，因此可能有助于促进戒烟。然而，最近的研究表明，电子烟对心血管系统不应完全无害。
审查目的
本综述旨在建立对香烟和电子烟相关心血管毒性的整体视角。
审查的关键科学概念
本综述采用不良结果途径（AOP）框架作为关键工具，旨在阐明香烟和电子烟暴露引起的分子起始事件（MIE）与心血管不良结果之间的关联。由于活性氧（ROS）的过量产生已被广泛认为在香烟烟雾相关的CVD中发挥关键作用，并且也可能参与电子烟引起的毒性作用，因此ROS过量产生和随后的氧化应激被认为是该框架的重要组成部分。据我们所知，这应该是第一个关注香烟和电子烟相关心血管毒性的 AOP 框架，我们希望我们的工作能够成为探索心血管损伤生物标志物和新疗法的指南。
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