Diabetologia ( IF 8.4 ) Pub Date : 2022-08-22 , DOI: 10.1007/s00125-022-05778-3 Alice L J Carr 1 , Carmella Evans-Molina 2, 3, 4, 5, 6, 7, 8 , Richard A Oram 1
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First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future.
Graphical abstract
中文翻译：
1型糖尿病的精准医学
以人为本的护理方法最初由早期糖尿病临床医生设想，是一个理想的目标，旨在使胰岛素治疗与每个人的独特需求相匹配。自胰岛素发现以来的 100 年来，这一目标已发展到包括 1 型糖尿病诊断、治疗、预防和预测的个性化方法。这些进步得益于对 1 型糖尿病作为一种自身免疫性疾病的认识，以及我们对糖尿病病理生理学、遗传学和自然史的理解的进步，这些进步与胰岛素输送、血糖监测和自我管理工具的进步同时发生。 。在这篇综述中，我们讨论了这些个性化方法如何改善糖尿病护理，以及加深对发病机制和人类生物学的理解如何为未来的精准医疗提供信息。
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