Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, the role of circ_0026359 in GC progression remains unclear. This study aims to analyze the role of circ_0026359 in GC development and the underlying mechanism. The results showed that compared with controls, GC tissues and cells displayed high circ_0026359 and HOXA9 expression, and low miR-140-3p expression. Depletion of circ_0026359 repressed cell proliferation, migration, invasion and glycolysis, and induced cell apoptosis. Circ_0026359 knockdown inhibited neoplasm growth in vivo. Under-expression of miR-140-3p, a target miRNA of circ_0026359, relieved the effects of circ_0026359 knockdown on GC progression. Additionally, HOXA9 was regulated by the circ_0026359/miR-140-3p axis. Thus, circ_0026359 absence inhibited GC progression by miR-140-3p/HOXA9 pathway, which provided an effective therapeutic target for GC.

中文翻译：

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Circ_0026359 诱导 HOXA9 通过 miR-140-3p 调控胃癌恶性进展

最近的研究表明 circRNA 在胃癌 (GC) 进展中的关键作用。然而，circ_0026359 在 GC 进展中的作用仍不清楚。本研究旨在分析circ_0026359在GC发展中的作用及其潜在机制。结果显示，与对照组相比，GC组织和细胞的circ_0026359和HOXA9表达较高，而miR-140-3p表达较低。circ_0026359 的消耗抑制细胞增殖、迁移、侵袭和糖酵解，并诱导细胞凋亡。Circ_0026359 敲低抑制了体内肿瘤的生长。circ_0026359 的靶 miRNA miR-140-3p 的低表达减轻了 circ_0026359 敲低对 GC 进展的影响。此外，HOXA9 受 circ_0026359/miR-140-3p 轴的调节。因此，