Abstract

Background: Limited studies are available on fetal oxidative stress and endothelial dysfunction and their association with adverse fetal outcomes in hypertensive disorders of pregnancy (HDP). Method: Umbilical cord blood samples were collected at delivery from 134 pregnant women with HDP and 59 controls. Markers of oxidative stress, endothelial dysfunction and inflammation and adipokines were analyzed. Results were correlated with adverse fetal outcomes. Results: Malondialdehyde, total antioxidant status(TAS), ADMA and hsCRP levels were increased in late and early onset preeclampsia. Adiponectin levels were decreased in early onset preeclampsia. High ADMA levels were positively associated with preterm births and fetal mortality and high TAS, protein carbonyl content(PC), ADMA and low adiponectin levels were positively associated with low birth weight babies. Conclusion: Fetal systemic oxidative stress, endothelial dysfunction and inflammation were altered in early and late onset preeclampsia. High TAS, PC and ADMA levels and low adiponectin levels were positively associated with adverse fetal outcomes in HDP.

摘要

背景：关于胎儿氧化应激和内皮功能障碍及其与妊娠期高血压疾病 (HDP) 不良胎儿结局的关系的研究有限。方法：在分娩时采集 134 名 HDP 孕妇和 59 名对照组的脐带血样本。分析了氧化应激、内皮功能障碍和炎症以及脂肪因子的标志物。结果与不良胎儿结局相关。结果：丙二醛、总抗氧化状态（TAS）、ADMA和hsCRP水平在迟发型和早发型先兆子痫中升高。脂联素水平在早发性先兆子痫中降低。高 ADMA 水平与早产和胎儿死亡率呈正相关，高 TAS、蛋白质羰基含量 (PC)、ADMA 和低脂联素水平与低出生体重婴儿呈正相关。结论：胎儿全身氧化应激、内皮功能障碍和炎症在早发和晚发先兆子痫中发生改变。高 TAS、PC 和 ADMA 水平以及低脂联素水平与 HDP 的不良胎儿结局呈正相关。