The first small molecule that can activate cGAS-STING in a photocontrollable way is reported. Upon irradiation, Pt1 and Pt2 can damage mitochondrial DNA, the nuclear envelope and nuclear DNA sequentially, which effectively releases DNA into cytoplasm to activate the cGAS-STING pathway both in vitro and in vivo.

中文翻译：

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用于癌症免疫治疗的铂 (II) 三苯胺复合物同时光激活 cGAS-STING 通路和细胞焦亡

报道了第一个可以光控方式激活 cGAS-STING 的小分子。照射后，Pt1和Pt2可依次破坏线粒体 DNA、核膜和核 DNA，从而有效地将 DNA 释放到细胞质中，从而在体外和体内激活 cGAS-STING 通路。