Background

The investigation of lncRNAs has provided a novel perspective for elucidating mechanisms underlying diverse physiological and pathological processes. Compelling evidence has revealed an intrinsic link between lncRNAs and lipid metabolism, demonstrating that lncRNAs-induced disruption of lipid metabolism and signaling contribute to the development of multiple cancers and some other diseases, including obesity, fatty liver disease, and cardiovascular disease.

Aimof Review

The current review summarizes the recent advances in basic research about lipid metabolism and lipid signaling-related lncRNAs. Meanwhile, the potential and challenges of targeting lncRNA for the therapy of cancers and other lipid metabolism-related diseases are also discussed.

Key Scientific Concept of Review

Compared with the substantial number of lncRNA loci, we still know little about the role of lncRNAs in metabolism. A more comprehensive understanding of the function and mechanism of lncRNAs may provide a new standpoint for the study of lipid metabolism and signaling. Developing lncRNA-based therapeutic approaches is an effective strategy for lipid metabolism-related diseases.

中文翻译：

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长链非编码 RNA 在脂质代谢和信号传导中的当前进展和未来展望

背景

lncRNA 的研究为阐明不同生理和病理过程背后的机制提供了一个新的视角。令人信服的证据揭示了 lncRNA 与脂质代谢之间的内在联系，表明 lncRNA 诱导的脂质代谢和信号传导破坏导致多种癌症和其他一些疾病的发展，包括肥胖、脂肪肝和心血管疾病。

审查的目的

本综述总结了脂质代谢和脂质信号相关lncRNA基础研究的最新进展。同时，还讨论了靶向 lncRNA 治疗癌症和其他脂质代谢相关疾病的潜力和挑战。

审查的关键科学概念

与大量的lncRNA位点相比，我们对lncRNA在代谢中的作用知之甚少。更全面地了解lncRNAs的功能和机制可能为脂质代谢和信号传导的研究提供新的视角。开发基于 lncRNA 的治疗方法是脂质代谢相关疾病的有效策略。