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PYGBacking on glycogen metabolism to fuel early memory T cell recall responses
Molecular Cell ( IF 14.5 ) Pub Date : 2022-08-18 , DOI: 10.1016/j.molcel.2022.07.016 Joseph Longo 1 , McLane J Watson 1 , Matthew J Vos 1 , Kelsey S Williams 1 , Russell G Jones 1
中文翻译：
PYG支持糖原代谢以促进早期记忆T细胞回忆反应
更新日期：2022-08-18
Molecular Cell ( IF 14.5 ) Pub Date : 2022-08-18 , DOI: 10.1016/j.molcel.2022.07.016 Joseph Longo 1 , McLane J Watson 1 , Matthew J Vos 1 , Kelsey S Williams 1 , Russell G Jones 1
Affiliation
Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8+ memory T (Tmem) cells. PYGB-dependent glycogen mobilization provides a carbon source to support glycolysis and early Tmem cell recall responses.
中文翻译：
PYG支持糖原代谢以促进早期记忆T细胞回忆反应
张等。(2022) 显示 TCR 信号促进 CD8 +记忆 T (Tmem) 细胞中糖原磷酸化酶 B (PYGB) 的磷酸化和激活。PYGB 依赖性糖原动员提供碳源以支持糖酵解和早期 Tmem 细胞召回反应。
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