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Enhancers have more cofactor specificity than we think: A potential new way to classify enhancers based on their functional cofactor requirements
Molecular Cell ( IF 14.5 ) Pub Date : 2022-08-18 , DOI: 10.1016/j.molcel.2022.07.015
Blanca Pijuan-Sala 1 , Eileen E M Furlong 1
Affiliation  

By systematically assessing the effects of depleting eight cofactors on enhancer activity, Neumayr et al. (2022) found that different enhancers have different requirements for some perceived universal cofactors. While some cofactors influence enhancer strength, others affect enhancer-promoter specificity.



中文翻译:

增强子具有比我们想象的更多的辅因子特异性:一种潜在的新方法来根据其功能辅因子要求对增强子进行分类

Neumayr 等人通过系统地评估消耗八种辅因子对增强子活性的影响。(2022) 发现不同的增强剂对一些感知到的通用辅因子有不同的要求。虽然一些辅因子会影响增强子的强度,但其他的会影响增强子-启动子的特异性。

更新日期:2022-08-18
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