Background and aim: Takayasu's arteritis (TA) is a chronic inflammation that frequently involves the aorta and its major branches. It has been known that atherosclerosis can occur in some TA patients. Objectives: This study aimed to identify the risk factors associated with the development of atherosclerosis in TA. Methods: This retrospective study enrolled a total of 101 TA patients. All patients were divided into two groups according to the absence or presence of atherosclerosis. Baseline demographic features and clinical characteristics were compared between two groups. A logistic model was applied to determine the risk factors associated with the development of atherosclerosis. Results: Our data suggested that the disease duration of patients in the atherosclerosis group was significantly longer than that of patients in the non-atherosclerosis group [96(18.00, 180.00) versus 48.00(12.00, 111.00) months] (P = .015). In addition, the average age of patients with atherosclerosis was significantly older compared to patients without atherosclerosis [44.00(38.00, 48.00)versus 28.50(24.00，37.00)years] (P < .001). Logistic regression analysis showed that the risk of developing atherosclerosis increased by 9.2% per 1 year increase in the disease duration (P = .005, OR 1.092, 95%CI: 1.027-1.162). Patients with TG/HDL-C ratio more than 0.8875 were associated with a 5.861fold increase of risk developing atherosclerosis (P < .001, OR 5.861, 95%CI: 2.299-14.939). Conclusion: Our study indicated that prolonged disease duration and elevated TG/HDL-C ratio are associated with the development of atherosclerosis in TA patients.

背景和目的： Takayasu 动脉炎 (TA) 是一种慢性炎症，经常累及主动脉及其主要分支。众所周知，某些 TA 患者会发生动脉粥样硬化。目的：本研究旨在确定与 TA 动脉粥样硬化发展相关的危险因素。方法：这项回顾性研究共招募了 101 名 TA 患者。根据有无动脉粥样硬化将所有患者分为两组。比较两组的基线人口统计学特征和临床特征。应用逻辑模型来确定与动脉粥样硬化发展相关的危险因素。结果：我们的数据表明，动脉粥样硬化组患者的病程明显长于非动脉粥样硬化组患者[96(18.00, 180.00) vs 48.00(12.00, 111.00)个月] ( P  = .015)。此外，动脉粥样硬化患者的平均年龄显着高于非动脉粥样硬化患者[44.00(38.00, 48.00)对28.50(24.00，37.00)岁] ( P  <  .001)。Logistic回归分析显示，病程每增加1年，发生动脉粥样硬化的风险增加9.2%（P  =0.005，OR 1.092，95%CI：1.027-1.162）。TG/HDL-C 比值超过 0.8875 的患者发生动脉粥样硬化的风险增加 5.861 倍（P <  .001，或 5.861，95%CI：2.299-14.939）。结论：我们的研究表明，延长的病程和升高的 TG/HDL-C 比值与 TA 患者动脉粥样硬化的发展有关。