Resident memory T cells (T RM ) form a distinct type of T memory cells that stably resides in tissues. T RM form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses mediated by pathogens, cancer, and possibly autoantigens during autoimmunity. T RM express residence gene signatures, functional properties of both memory and effector cells, and remarkable plasticity. T RM have a well-established role in pathogen immunity, whereas their role in antitumor immune responses and immunotherapy is currently evolving. As T RM form the most abundant T memory cell population in nonlymphoid tissues, they are attractive targets for therapeutic exploitation. Here, we provide a concise review of the development and physiological role of CD8 + T RM , their involvement in diseases, and their potential therapeutic exploitation.

中文翻译：

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组织驻留记忆 T 细胞在感染和癌症中的演变作用

驻留记忆 T 细胞 (TR M) 形成稳定存在于组织中的独特类型的 T 记忆细胞。吨R M形成免疫传感网络的一个组成部分，具有控制局部免疫稳态的能力，并参与自身免疫过程中由病原体、癌症和可能的自身抗原介导的免疫反应。吨R M表达驻留基因特征、记忆细胞和效应细胞的功能特性以及显着的可塑性。吨R M在病原体免疫中具有公认的作用，而它们在抗肿瘤免疫反应和免疫治疗中的作用目前正在发展。作为 TR M形成非淋巴组织中最丰富的 T 记忆细胞群，它们是治疗开发的有吸引力的目标。在这里，我们简要回顾了 CD8 的发育和生理作用+吨R M，他们对疾病的参与，以及他们潜在的治疗开发。