Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic,Drug Delivery and Translational Research

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Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic
Drug Delivery and Translational Research ( IF 5.7 ) Pub Date : 2022-08-17 , DOI: 10.1007/s13346-022-01228-0
Samer R Abulateefeh ₁

Affiliation

The excellent properties of polyesters combined with their ease of synthesis and modification enabled their wide use in the pharmaceutical industry. This has been translated into the approval of several injectable depots for clinical use. Long-acting depots for leuprolide acetate were among the first and most successful examples including Lupron Depot^® and ELIGARD^®. Studying these products is of great interest for researchers in both industry and academia. This will undoubtedly pave the road for the development of new as well as generic long-acting depots for a variety of drugs.

Graphical abstract

中文翻译：

用于醋酸亮丙瑞林的长效可注射 PLGA/PLA 储库：从实验室到临床的成功转化

聚酯的优异性能及其易于合成和改性使其在制药工业中得到广泛应用。这已转化为批准用于临床使用的几种可注射长效制剂。醋酸亮丙瑞林的长效储库是最早也是最成功的例子，包括 Lupron Depot ^®和 ELIGARD ^®。研究这些产品引起了工业界和学术界研究人员的极大兴趣。这无疑将为各种药物的新型长效长效贮库的开发铺平道路。

图形概要

更新日期：2022-08-18

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