当前位置: X-MOL 学术J. Cell Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse
Journal of Cell Biology ( IF 7.4 ) Pub Date : 2022-08-15 , DOI: 10.1083/jcb.202208015
Mitchell S Wang 1 , Morgan Huse 1
Affiliation  

Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin architecture by locally depleting phosphatidylinositol 4,5 bisphosphate.

中文翻译:

磷酸肌醇:B 细胞免疫突触的肌动蛋白动力学

肌动蛋白重塑通过使 B 细胞抗原受体在免疫突触中聚集来促进 B 细胞活化。在最新一期的 JCB 中,Droubi 等人。 (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018) 发现这一过程是由脂质磷酸酶 INPP5B 启动的,该酶通过局部消耗磷脂酰肌醇 4,5 二磷酸来塑造突触肌动蛋白结构。
更新日期:2022-08-15
down
wechat
bug