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Signal On–Off Electrochemical Sensor for Glutathione Based on a AuCu-Decorated Zr-Containing Metal–Organic Framework via Solid-State Electrochemistry of Cuprous Chloride
ACS Sensors ( IF 8.2 ) Pub Date : 2022-08-16 , DOI: 10.1021/acssensors.2c01221 Dan Cheng 1 , Peipei Li 1 , Zhenjuan Xu 1 , Xiang Liu 1 , Youyu Zhang 1 , Meiling Liu 1 , Shouzhuo Yao 1
ACS Sensors ( IF 8.2 ) Pub Date : 2022-08-16 , DOI: 10.1021/acssensors.2c01221 Dan Cheng 1 , Peipei Li 1 , Zhenjuan Xu 1 , Xiang Liu 1 , Youyu Zhang 1 , Meiling Liu 1 , Shouzhuo Yao 1
Affiliation
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A novel signal on–off glutathione (GSH) electrochemical sensor was developed based on a AuCu bimetal-decorated Zr-containing metal–organic framework (Zr-MOF), in which a signal amplification strategy promoted by solid-state electrochemistry of cuprous chloride (CuCl) was used. The Zr-MOF with a large surface area can be effectively used as the substrate for the in situ growth of AuCu bimetals to obtain the Zr-MOF@AuCu nanocomposite. The interaction between Cu in Zr-MOF@AuCu and Cl– in the solution accompanied with the formation of CuCl displays an enlarged stable oxidation current, which greatly declines with the addition of GSH owing to the specific Cu–GSH interaction. The conversion of CuCl into Cu-GSH triggered the “crowding-out effect” and resulted in a sharp drop in the peak current of CuCl, which can realize the ultrasensitive and selective detection of GSH. The detection mechanism was investigated, and the detection range was 10 pM–1 mM with the detection limit as low as 2.67 pM. The special response mechanism for the detection of GSH allows the highly selective detection of GSH in various real samples with reliable results, endowing the proposed electroanalysis sensor with broad application prospects in biological and food analysis.
中文翻译：
基于 AuCu 修饰的含锆金属有机骨架的谷胱甘肽信号开关电化学传感器，通过氯化亚铜的固态电化学
基于 AuCu 双金属修饰的含 Zr 金属有机框架（Zr-MOF）开发了一种新型信号开关谷胱甘肽（GSH）电化学传感器，其中氯化亚铜的固态电化学促进了信号放大策略（使用 CuCl)。具有大表面积的 Zr-MOF 可以有效地用作 AuCu 双金属原位生长的基底，以获得 Zr-MOF@AuCu 纳米复合材料。Zr-MOF@AuCu中Cu与Cl-的相互作用在溶液中伴随着 CuCl 的形成显示出稳定的氧化电流增大，由于特定的 Cu-GSH 相互作用，随着 GSH 的加入大大降低。CuCl转化为Cu-GSH引发“挤出效应”，导致CuCl峰电流急剧下降，可实现GSH的超灵敏选择性检测。研究了检测机制，检测范围为 10 pM–1 mM，检测限低至 2.67 pM。GSH检测的特殊响应机制使得GSH在各种真实样品中的高选择性检测和可靠的结果赋予所提出的电分析传感器在生物和食品分析中的广阔应用前景。
更新日期：2022-08-16
中文翻译：
基于 AuCu 修饰的含锆金属有机骨架的谷胱甘肽信号开关电化学传感器，通过氯化亚铜的固态电化学
基于 AuCu 双金属修饰的含 Zr 金属有机框架（Zr-MOF）开发了一种新型信号开关谷胱甘肽（GSH）电化学传感器，其中氯化亚铜的固态电化学促进了信号放大策略（使用 CuCl)。具有大表面积的 Zr-MOF 可以有效地用作 AuCu 双金属原位生长的基底，以获得 Zr-MOF@AuCu 纳米复合材料。Zr-MOF@AuCu中Cu与Cl-的相互作用在溶液中伴随着 CuCl 的形成显示出稳定的氧化电流增大，由于特定的 Cu-GSH 相互作用，随着 GSH 的加入大大降低。CuCl转化为Cu-GSH引发“挤出效应”，导致CuCl峰电流急剧下降，可实现GSH的超灵敏选择性检测。研究了检测机制，检测范围为 10 pM–1 mM，检测限低至 2.67 pM。GSH检测的特殊响应机制使得GSH在各种真实样品中的高选择性检测和可靠的结果赋予所提出的电分析传感器在生物和食品分析中的广阔应用前景。
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