ABSTARCT

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic syndrome. Flagellum-dependent motility plays diverse roles in the pathogenesis of EHEC O157:H7, including its migration to an optimal host site, adherence and colonization, survival at the infection site, and post-infection dispersal. However, it is very expensive for cellular economy in terms of the number of genes and the energy required for flagellar biosynthesis and functioning. Furthermore, the flagellar filament bears strong antigenic properties that induce a strong host immune response. Consequently, the flagellar gene expression and biosynthesis are highly regulated to occur at the appropriate time and place by different regulatory influences. The present review focuses on the regulatory mechanisms of EHEC O157:H7 motility and flagellar biosynthesis, especially in terms of flagellar gene regulation by environmental factors, regulatory proteins, and small regulatory RNAs.

摘要

肠出血性大肠杆菌(EHEC) O157:H7 是一种人类病原体，可导致多种疾病，如出血性结肠炎和致死性溶血性尿毒症综合征。鞭毛依赖性运动在 EHEC O157:H7 的发病机制中发挥着不同的作用，包括其向最佳宿主部位的迁移、粘附和定植、感染部位的存活和感染后的扩散。然而，就基因数量和鞭毛生物合成和功能所需的能量而言，细胞经济非常昂贵。此外，鞭毛丝具有很强的抗原特性，可诱导强烈的宿主免疫反应。因此，鞭毛基因的表达和生物合成受到高度调节，以通过不同的调节影响在适当的时间和地点发生。本综述侧重于 EHEC O157 的监管机制：