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Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols
Redox Biology ( IF 10.7 ) Pub Date : 2022-08-14 , DOI: 10.1016/j.redox.2022.102439
Stefan Schildknecht 1 , Alex von Kriegsheim 2 , Ksenija Vujacic-Mirski 3 , Fabio Di Lisa 4 , Volker Ullrich 5 , Andreas Daiber 6
Affiliation  

Nitrosation of critical thiols has been elaborated as reversible posttranslational modification with regulatory function in multiple disorders. Reversibility of S-nitrosation is generally associated with enzyme-mediated one-electron reductions, catalyzed by the thioredoxin system, or by nitrosoglutathione reductase.

中文翻译:


通过亚硝基硫醇的超氧化物介导的脱亚硝化回收还原的硫醇基团



关键硫醇的亚硝化已被阐述为可逆的翻译后修饰,在多种疾病中具有调节功能。 S-亚硝化的可逆性通常与酶介导的单电子还原有关,由硫氧还蛋白系统或亚硝基谷胱甘肽还原酶催化。
更新日期:2022-08-14
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