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Engineering of Near-Infrared-Activated Lignin–Polydopamine–Nanosilver Composites for Highly Efficient Sterilization
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2022-08-15 , DOI: 10.1021/acsabm.2c00474 Yingchun Zhang 1 , Yalin Wang 1 , Zhixian Li 1 , Dongjie Yang 1 , Xueqing Qiu 2
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2022-08-15 , DOI: 10.1021/acsabm.2c00474 Yingchun Zhang 1 , Yalin Wang 1 , Zhixian Li 1 , Dongjie Yang 1 , Xueqing Qiu 2
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Photothermal synergistic antimicrobial therapy is considered a promising strategy to cope with antibiotic-resistant bacterial infections. In this work, lignin-based polydopamine nanosilver composites (LS–PDA–Ag) were engineered by a two-step process including self-assembly and microwave-assisted reduction. First, sodium lignosulfonate (LS) was not only used as a carrier to disperse polydopamine (PDA) and silver nanoparticles (AgNPs), but also used to reduce Ag+ for producing AgNPs. Second, PDA could promote the reduction of Ag+ and enhance the photothermal effect of AgNPs to further improve antibacterial efficiency. Finally, LS, AgNPs, and PDA complement each other, forming a synergistic photothermal antibacterial mechanism, achieving efficient bacterial killing within a short time. The antibacterial test of LS–PDA–Ag confirmed that 7.6 log10 CFU/mL of Escherichia coli were killed in 10 min under near-infrared irradiation. Furthermore, the LS–PDA–Ag can be blended with waterborne polyurethane to synthesize hybrid films, which also results in rapid sterilization and mechanical performance improvement. Considering the highly effective antibacterial activity of the LS–PDA–Ag composite, this work may provide perspectives on the design of green photothermal antibacterial materials.
中文翻译：
用于高效灭菌的近红外激活木质素-聚多巴胺-纳米银复合材料的工程
光热协同抗菌疗法被认为是应对抗生素耐药细菌感染的一种有前景的策略。在这项工作中，基于木质素的聚多巴胺纳米银复合材料（LS-PDA-Ag）是通过自组装和微波辅助还原的两步过程设计的。首先，木质素磺酸钠（LS）不仅用作分散聚多巴胺（PDA）和纳米银（AgNPs）的载体，而且还用于还原Ag +以生产AgNPs。其次，PDA可以促进Ag +的还原，增强AgNPs的光热效应，进一步提高抗菌效率。最后，LS、AgNPs和PDA相互补充，形成协同光热抗菌机制，在短时间内实现高效杀灭细菌。 LS-PDA-Ag的抗菌测试证实，在近红外照射下，10分钟内可杀死7.6 log 10 CFU/mL的大肠杆菌。此外，LS-PDA-Ag可以与水性聚氨酯共混合成杂化薄膜，这也可以实现快速灭菌和机械性能的提高。考虑到LS-PDA-Ag复合材料的高效抗菌活性，这项工作可能为绿色光热抗菌材料的设计提供视角。
更新日期：2022-08-15
中文翻译：
用于高效灭菌的近红外激活木质素-聚多巴胺-纳米银复合材料的工程
光热协同抗菌疗法被认为是应对抗生素耐药细菌感染的一种有前景的策略。在这项工作中，基于木质素的聚多巴胺纳米银复合材料（LS-PDA-Ag）是通过自组装和微波辅助还原的两步过程设计的。首先，木质素磺酸钠（LS）不仅用作分散聚多巴胺（PDA）和纳米银（AgNPs）的载体，而且还用于还原Ag +以生产AgNPs。其次，PDA可以促进Ag +的还原，增强AgNPs的光热效应，进一步提高抗菌效率。最后，LS、AgNPs和PDA相互补充，形成协同光热抗菌机制，在短时间内实现高效杀灭细菌。 LS-PDA-Ag的抗菌测试证实，在近红外照射下，10分钟内可杀死7.6 log 10 CFU/mL的大肠杆菌。此外，LS-PDA-Ag可以与水性聚氨酯共混合成杂化薄膜，这也可以实现快速灭菌和机械性能的提高。考虑到LS-PDA-Ag复合材料的高效抗菌活性，这项工作可能为绿色光热抗菌材料的设计提供视角。
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