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Glucagon receptor antagonists might stimulate β-cell expansion
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2022-08-15 , DOI: 10.1038/s41574-022-00735-x
Maria F Rubin de Celis 1 , Susan Bonner-Weir 2
Affiliation  

In a recent issue of Cell Reports, Xi et al. reported on their studies of an anti-glucagon receptor antibody in several mouse models of insulin-deficient diabetes mellitus, in which they show substantial increase in β-cell mass from enhanced replication and transdifferentiation of glucagon-expressing α-cells to insulin-expressing β-cells.

中文翻译:

胰高血糖素受体拮抗剂可能会刺激 β 细胞扩张

在最近一期的 Cell Reports 中,Xi 等人。报道了他们在几种胰岛素缺乏型糖尿病小鼠模型中对抗胰高血糖素受体抗体的研究,在这些模型中,他们表明,由于表达胰高血糖素的 α 细胞向表达胰岛素的 β 细胞的复制和转分化增强,β 细胞质量显着增加-细胞。
更新日期:2022-08-15
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