Palindromic rheumatism (PR) is an infrequent form of periodic arthritis. Based on the similarity of the pathogenesis of PR to autoinflammatory syndromes, we previously found that the dominant-active splice variant of the inflammasome adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which lacks exon 2 (Δexon2), is expressed in Japanese patients with PR.

中文翻译：

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在日本回文风湿病患者中发现的 ASC 剪接变体的表达受 rs8056505 单核苷酸多态性和白细胞介素 1 β 的调节。

回文风湿病 (PR) 是一种罕见的周期性关节炎。基于 PR 发病机制与自身炎症综合征的相似性，我们之前发现炎症小体衔接蛋白的显性活性剪接变体，即含有 CARD (ASC) 的凋亡相关斑点样蛋白，其缺乏外显子 2 (Δexon2) , 在日本 PR 患者中表达。