Silica-grafted polyamines developed for CO₂ capture are capable of reversibly and selectively capturing CO₂ at ambient temperature. In this study, the feasibility of solid phase chemical adsorbents for purifying [¹¹C]CO₂ from cyclotron target gas was investigated as an alternative to physical adsorption. Silica grafted polyethyleneimine (Si-g-PEI) demonstrated a high selectivity for [¹¹C]CO₂ at room temperature with no detectable radiochemical impurities. Capture efficiencies from cyclotron target gas were 79 ± 12% for Si-g-PEI. Pure [¹¹C]CO₂ was obtained in under 10 min via temperature-swing desorption. Si-g-PEI was easily regenerated with mild heating, though capture efficiencies decreased over multiple cycles. As a proof-of-concept, the positron emission tomography (PET) radiopharmaceutical [¹¹C]SL2511.88 was successfully synthesized from Si-g-PEI purified [¹¹C]CO₂, providing molar activities on par with conventional methods. This work presents the first reusable, solid phase chemical adsorbents for capture and purification of [¹¹C]CO₂ under mild conditions. Future work will focus on improved material longevity using materials with high thermal and oxidative stability.

_{为CO 2}捕获而开发的二氧化硅接枝多胺能够在环境温度下可逆且选择性地捕获CO _{2 。}在这项研究中，研究了固相化学吸附剂从回旋加速器目标气体中纯化 [ ¹¹ C]CO ₂作为物理吸附的替代方案的可行性。二氧化硅接枝聚乙烯亚胺 (Si-g-PEI)在室温下表现出对 [ ¹¹ C]CO _{2的高选择性，没有可检测到的放射化学杂质。}对于 Si-g-PEI，回旋加速器目标气体的捕获效率为 79 ± 12%。纯[ ¹¹ C]CO ₂通过变温解吸在 10 分钟内获得。Si-g-PEI 通过温和的加热很容易再生，尽管捕获效率在多个循环中下降。作为概念验证，正电子发射断层扫描 (PET) 放射性药物 [ ¹¹ C]SL2511.88 由 Si-g-PEI 纯化的 [ ¹¹ C]CO ₂成功合成，提供与传统方法相当的摩尔活性。这项工作提出了第一个可重复使用的固相化学吸附剂，用于在温和条件下捕获和纯化 [ ¹¹ C]CO _{2 。}未来的工作将集中在使用具有高热稳定性和氧化稳定性的材料来提高材料的使用寿命。