Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts,American Journal of Ophthalmology

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Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts
American Journal of Ophthalmology ( IF 4.1 ) Pub Date : 2022-08-13 , DOI: 10.1016/j.ajo.2022.08.006
Henry Marshall ₁ , Ella C Berry ₁ , Santiago Diaz Torres ₂ , Sean Mullany ₃ , Joshua Schmidt ₁ , Daniel Thomson ₁ , Thi Thi Nguyen ₁ , Lachlan Sw Knight ₁ , Georgina Hollitt ₁ , Ayub Qassim ₁ , Antonia Kolovos ₁ , Bronwyn Ridge ₁ , Angela Schulz ₄ , Stewart Lake ₁ , Richard A Mills ₁ , Ashish Agar ₅ , Anna Galanopoulos ₆ , John Landers ₁ , Paul R Healey ₇ , Stuart L Graham ₄ , Alex W Hewitt ₈ , Robert J Casson ₆ , Stuart MacGregor ₂ , Owen M Siggs ₉ , Jamie E Craig ₁

Affiliation

From Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia (H.M, E.C.B, S.M, J.S, D.T, T.T.N, L.S.W.K, G.H, A.Q, A.K, B.R, S.L, R.A.M, J.L, O.M.S, J.E.C).
QIMR Berghofer Medical Research Institute, Herston, Australia (S.D.T, S.M).
From Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia (H.M, E.C.B, S.M, J.S, D.T, T.T.N, L.S.W.K, G.H, A.Q, A.K, B.R, S.L, R.A.M, J.L, O.M.S, J.E.C); QIMR Berghofer Medical Research Institute, Herston, Australia (S.D.T, S.M).
Faculty of Health and Medical Sciences, Macquarie University, Sydney, Australia (A.S, S.L.G).
Department of Ophthalmology, University of New South Wales, Sydney, Australia (A.A).
Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, Australia (A.G, R.J.C).
Centre for Vision Research, University of Sydney, Sydney, Australia (P.R.H).
Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia (A.W.H).
From Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia (H.M, E.C.B, S.M, J.S, D.T, T.T.N, L.S.W.K, G.H, A.Q, A.K, B.R, S.L, R.A.M, J.L, O.M.S, J.E.C); Garvan Institute of Medical Research, Sydney, Australia (O.M.S).

Purpose

To evaluate the relationship between body mass index (BMI) and glaucoma progression.

Design

Multicohort observational study.

Methods

This study combined a retrospective longitudinal analysis of suspect and early manifest primary open angle glaucoma cases from the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study with 2 replication cohorts from the UK Biobank and the Canadian Longitudinal Study of Ageing (CLSA). In the PROGRESSA study, multivariate analysis correlated BMI with longitudinal visual field progression in 471 participants. The BMI was then associated with glaucoma diagnosis and cross-sectional vertical cup-disc ratio (VCDR) measurements in the UK Biobank, and finally prospectively associated with longitudinal change in VCDR in the CLSA study.

Results

In the PROGRESSA study, a lower BMI conferred a faster rate of visual field progression (mean duration of monitoring (5.28 ± 1.80 years (10.6 ± 3.59 visits) (β 0.04 dB/year/SD95% CI [0.005, 0.069]; P = .013). In the UK Biobank, a 1 standard deviation lower BMI was associated with a worse cross-sectional VCDR (β –0.048/SD 95% CI [–0.056, 0.96]; P < .001) and a 10% greater likelihood of glaucoma diagnosis, as per specialist grading of retinal fundus imaging (OR 0.90 95% CI [0.84, 0.98]; P = .011). Similarly, a lower BMI was associated with a greater risk of glaucoma diagnosis as per International Classification of Disease data (OR 0.94/SD; 95% CI [0.91, 0.98]; P = .002). Body mass index was also positively correlated with intraocular pressure (β 0.11/SD; 95% CI [0.06, 0.15]; P < .001). Finally, a lower BMI was then associated with greater VCDR change in the CLSA (β –0.007/SD; 95% CI [–0.01, –0.001]; P = .023).

Conclusions

Body mass index correlated with longitudinal and cross-sectional glaucomatous outcomes. This supports previous work illustrating a correlation between BMI and glaucoma.

中文翻译：

三个队列中体重指数与原发性开角型青光眼的关联

目的

评估体重指数 (BMI) 与青光眼进展之间的关系。

设计

多队列观察研究。

方法

这项研究结合了来自青光眼进展风险的疑似和早期明显原发性开角型青光眼病例的回顾性纵向分析：具有显着关联的相关 SNP (PROGRESSA) 研究与来自英国生物库和加拿大衰老纵向研究 (CLSA) 的 2 个复制队列). 在 PROGRESSA 研究中，多变量分析将 471 名参与者的 BMI 与纵向视野进展相关联。然后，BMI 与英国生物库中的青光眼诊断和横截面垂直杯盘比 (VCDR) 测量值相关联，最后在 CLSA 研究中前瞻性地与 VCDR 的纵向变化相关联。

结果

在 PROGRESSA 研究中，BMI 越低，视野进展速度越快（平均监测持续时间（5.28 ± 1.80 年（10.6 ± 3.59 次就诊））（β 0.04 dB/年/SD95% CI [0.005, 0.069]；P = .013)。在英国生物样本库中，BMI 降低 1 个标准差与更差的横截面 VCDR (β –0.048/SD 95% CI [–0.056, 0.96]； P < .001) 和高 10%相关青光眼诊断的可能性，根据视网膜眼底成像的专家分级（OR 0.90 95% CI [0.84, 0.98]；P = .011）。同样，根据国际分类，较低的 BMI 与较高的青光眼诊断风险相关疾病数据 (OR 0.94/SD; 95% CI [0.91, 0.98]; P =.002）。体重指数也与眼内压呈正相关（β 0.11/SD；95% CI [0.06，0.15]；P < .001）。最后，较低的 BMI 与 CLSA 中较大的 VCDR 变化相关（β –0.007/SD；95% CI [–0.01，–0.001]；P = .023）。