Adjunct therapy with anticholinergic agents has been proposed to reduce the incidence of extrapyramidal side effects such as akathisia following treatment with neuroleptics or metoclopramide. This systematic review assessed the effectiveness of anticholinergic agents to prevent neuroleptic or metoclopramide-induced akathisia in patients presenting to the emergency department (ED) with benign headache.

中文翻译：

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辅助抗胆碱能疗法预防急诊原发性头痛患者静坐不能：一项系统评价

已经提出用抗胆碱能药物进行辅助治疗以降低锥体外系副作用的发生率，例如用抗精神病药或甲氧氯普胺治疗后的静坐不能。该系统评价评估了抗胆碱能药物在因良性头痛就诊于急诊科 (ED) 的患者中预防抗精神病药或甲氧氯普胺诱导的静坐不能的有效性。